YES! PoolRx works great with those systems. PoolRx minerals are not affected by UV or Ozone. Even better, the minerals are in solution throughout the entire body of water, preventing all types of algae and freeing up chlorine to be more available. UV and Ozone systems only oxidize the water for a few seconds. The water is then exposed to contaminants when it returns to the pool. This is where adding PoolRx to a UV or Ozone system really makes sense.